Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies
Identifieur interne : 006F62 ( Main/Exploration ); précédent : 006F61; suivant : 006F63Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies
Auteurs : Katherine S. Elliott [Royaume-Uni] ; Eleftheria Zeggini [Royaume-Uni] ; Mark I. Mccarthy [Royaume-Uni] ; Julius Gudmundsson [Islande] ; Patrick Sulem [Islande] ; Simon N. Stacey [Islande] ; Steinunn Thorlacius [Islande] ; Laufey Amundadottir [États-Unis] ; Henrik Grönberg [Suède] ; Jianfeng Xu [États-Unis] ; Valerie Gaborieau [France] ; Rosalind A. Eeles [Royaume-Uni] ; David E. Neal [Royaume-Uni] ; Jenny L. Donovan [Royaume-Uni] ; Freddie C. Hamdy [Royaume-Uni] ; Kenneth Muir [Royaume-Uni] ; Shih-Jen Hwang [États-Unis] ; Margaret R. Spitz [États-Unis] ; Brent Zanke [Canada] ; Luis Carvajal-Carmona [Royaume-Uni] ; Kevin M. Brown [États-Unis] ; Nicholas K. Hayward [Australie] ; Stuart Macgregor [Australie] ; Ian P. M. Tomlinson [Royaume-Uni] ; Mathieu Lemire [Canada] ; Christopher I. Amos [États-Unis] ; Joanne M. Murabito [États-Unis] ; William B. Isaacs [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; Paul Brennan [France] ; Rosa B. Barkardottir [Islande] ; Daniel F. Gudbjartsson [Islande] ; Thorunn Rafnar [Islande] ; David J. Hunter [États-Unis] ; Stephen J. Chanock [États-Unis] ; Kari Stefansson [Islande] ; John P. A. Ioannidis [Grèce, États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Abstract
Genome-wide association studies have found type 2 diabetes-associated variants in the
In a collaborative analysis, we collected data from GWAS of cancer phenotypes for the frequently reported variants of
The examined
Url:
DOI: 10.1371/journal.pone.0010858
PubMed: 20526366
PubMed Central: 2878330
Affiliations:
- Australie, Canada, France, Grèce, Islande, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Arizona, Auvergne-Rhône-Alpes, Caroline du Nord, Maryland, Massachusetts, Oxfordshire, Rhône-Alpes, Svealand, Texas
- Cambridge, Lyon, Oxford, Stockholm
- Université d'Oxford, Université de Cambridge
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Le document en format XML
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Brown</name><affiliation wicri:level="2"><nlm:aff id="aff19"><addr-line>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Tomlinson, Ian P M" sort="Tomlinson, Ian P M" uniqKey="Tomlinson I" first="Ian P. M." last="Tomlinson">Ian P. M. Tomlinson</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. 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Murabito</name><affiliation wicri:level="2"><nlm:aff id="aff21"><addr-line>Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><affiliation wicri:level="2"><nlm:aff id="aff22"><addr-line>The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="aff23"><addr-line>Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Pathology, Landspitali-University Hospital of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Pathology, Landspitali-University Hospital of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F." last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:aff id="aff26"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece</addr-line></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff28"><addr-line>Center for Genetic Epidemiology and Modelling, Tufts University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Genetic Epidemiology and Modelling, Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20526366</idno><idno type="pmc">2878330</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878330</idno><idno type="RBID">PMC:2878330</idno><idno type="doi">10.1371/journal.pone.0010858</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002B85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B85</idno><idno type="wicri:Area/Pmc/Curation">002A35</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A35</idno><idno type="wicri:Area/Pmc/Checkpoint">002592</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002592</idno><idno type="wicri:Area/Ncbi/Merge">000800</idno><idno type="wicri:Area/Ncbi/Curation">000800</idno><idno type="wicri:Area/Ncbi/Checkpoint">000800</idno><idno type="wicri:Area/Main/Merge">007480</idno><idno type="wicri:Area/Main/Curation">006F62</idno><idno type="wicri:Area/Main/Exploration">006F62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of Association of <italic>HNF1B</italic> Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies</title><author><name sortKey="Elliott, Katherine S" sort="Elliott, Katherine S" uniqKey="Elliott K" first="Katherine S." last="Elliott">Katherine S. Elliott</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Applied Statistical Genetics, Wellcome Trust Sanger Institute, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Applied Statistical Genetics, Wellcome Trust Sanger Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorlacius, Steinunn" sort="Thorlacius, Steinunn" uniqKey="Thorlacius S" first="Steinunn" last="Thorlacius">Steinunn Thorlacius</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Amundadottir, Laufey" sort="Amundadottir, Laufey" uniqKey="Amundadottir L" first="Laufey" last="Amundadottir">Laufey Amundadottir</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Oncogenetics Team, The Institute of Cancer Research, Sutton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oncogenetics Team, The Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Department of Social Medicine, University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Social Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation wicri:level="4"><nlm:aff id="aff13"><addr-line>Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Health Sciences Research Institute, University of Warwick, Coventry, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Framingham Study, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Framingham Study, National Heart, Lung, and Blood Institute, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R." last="Spitz">Margaret R. Spitz</name><affiliation wicri:level="2"><nlm:aff id="aff16"><addr-line>Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zanke, Brent" sort="Zanke, Brent" uniqKey="Zanke B" first="Brent" last="Zanke">Brent Zanke</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><addr-line>Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Carvajal Carmona, Luis" sort="Carvajal Carmona, Luis" uniqKey="Carvajal Carmona L" first="Luis" last="Carvajal-Carmona">Luis Carvajal-Carmona</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><affiliation wicri:level="2"><nlm:aff id="aff19"><addr-line>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Tomlinson, Ian P M" sort="Tomlinson, Ian P M" uniqKey="Tomlinson I" first="Ian P. M." last="Tomlinson">Ian P. M. Tomlinson</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:aff id="aff16"><addr-line>Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M." last="Murabito">Joanne M. Murabito</name><affiliation wicri:level="2"><nlm:aff id="aff21"><addr-line>Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><affiliation wicri:level="2"><nlm:aff id="aff22"><addr-line>The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="aff23"><addr-line>Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Pathology, Landspitali-University Hospital of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Pathology, Landspitali-University Hospital of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F." last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:aff id="aff26"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece</addr-line></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff28"><addr-line>Center for Genetic Epidemiology and Modelling, Tufts University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Genetic Epidemiology and Modelling, Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Genome-wide association studies have found type 2 diabetes-associated variants in the <italic>HNF1B</italic> gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in general versus a specific effect on prostate cancer only.</p></sec><sec><title>Methodology/Principal Findings</title><p>In a collaborative analysis, we collected data from GWAS of cancer phenotypes for the frequently reported variants of <italic>HNF1B</italic>, rs4430796 and rs7501939, which are in linkage disequilibrium (r<sup>2</sup> = 0.76, HapMap CEU). Overall, the analysis included 16 datasets on rs4430796 with 19,640 cancer cases and 21,929 controls; and 21 datasets on rs7501939 with 26,923 cases and 49,085 controls. Malignancies other than prostate cancer included colorectal, breast, lung and pancreatic cancers, and melanoma. Meta-analysis showed large between-dataset heterogeneity that was driven by different effects in prostate cancer and other cancers. The per-T2D-risk-allele odds ratios (95% confidence intervals) for rs4430796 were 0.79 (0.76, 0.83)] per G allele for prostate cancer (p<10<sup>−15</sup> for both); and 1.03 (0.99, 1.07) for all other cancers. Similarly for rs7501939 the per-T2D-risk-allele odds ratios (95% confidence intervals) were 0.80 (0.77, 0.83) per T allele for prostate cancer (p<10<sup>−15</sup> for both); and 1.00 (0.97, 1.04) for all other cancers. No malignancy other than prostate cancer had a nominally statistically significant association.</p></sec><sec><title>Conclusions/Significance</title><p>The examined <italic>HNF1B</italic> variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Inoue, M" uniqKey="Inoue M">M Inoue</name></author><author><name sortKey="Iwasaki, M" uniqKey="Iwasaki M">M Iwasaki</name></author><author><name sortKey="Otani, T" uniqKey="Otani T">T Otani</name></author><author><name sortKey="Sasazuki, S" uniqKey="Sasazuki S">S Sasazuki</name></author><author><name sortKey="Noda, M" uniqKey="Noda M">M Noda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stattin, P" uniqKey="Stattin P">P Stattin</name></author><author><name sortKey="Bjor, O" uniqKey="Bjor O">O 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J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author><author><name sortKey="Patsopoulos, Na" uniqKey="Patsopoulos N">NA Patsopoulos</name></author><author><name sortKey="Evangelou, E" uniqKey="Evangelou E">E Evangelou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petersen, Gm" uniqKey="Petersen G">GM Petersen</name></author><author><name sortKey="Amundadottir, L" uniqKey="Amundadottir L">L Amundadottir</name></author><author><name sortKey="Fuchs, Cs" uniqKey="Fuchs C">CS Fuchs</name></author><author><name sortKey="Kraft, P" uniqKey="Kraft P">P Kraft</name></author><author><name sortKey="Stolzenberg Solomon, Rz" uniqKey="Stolzenberg Solomon R">RZ Stolzenberg-Solomon</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Grèce</li><li>Islande</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Arizona</li><li>Auvergne-Rhône-Alpes</li><li>Caroline du Nord</li><li>Maryland</li><li>Massachusetts</li><li>Oxfordshire</li><li>Rhône-Alpes</li><li>Svealand</li><li>Texas</li></region><settlement><li>Cambridge</li><li>Lyon</li><li>Oxford</li><li>Stockholm</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Elliott, Katherine S" sort="Elliott, Katherine S" uniqKey="Elliott K" first="Katherine S." last="Elliott">Katherine S. Elliott</name></region><name sortKey="Carvajal Carmona, Luis" sort="Carvajal Carmona, Luis" uniqKey="Carvajal Carmona L" first="Luis" last="Carvajal-Carmona">Luis Carvajal-Carmona</name><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><name sortKey="Tomlinson, Ian P M" sort="Tomlinson, Ian P M" uniqKey="Tomlinson I" first="Ian P. M." last="Tomlinson">Ian P. M. Tomlinson</name><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name></country><country name="Islande"><noRegion><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name></noRegion><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F." last="Gudbjartsson">Daniel F. Gudbjartsson</name><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><name sortKey="Thorlacius, Steinunn" sort="Thorlacius, Steinunn" uniqKey="Thorlacius S" first="Steinunn" last="Thorlacius">Steinunn Thorlacius</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Amundadottir, Laufey" sort="Amundadottir, Laufey" uniqKey="Amundadottir L" first="Laufey" last="Amundadottir">Laufey Amundadottir</name></region><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M." last="Murabito">Joanne M. Murabito</name><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R." last="Spitz">Margaret R. Spitz</name><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name></country><country name="Suède"><region name="Svealand"><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name></region><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></country><country name="Canada"><noRegion><name sortKey="Zanke, Brent" sort="Zanke, Brent" uniqKey="Zanke B" first="Brent" last="Zanke">Brent Zanke</name></noRegion><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><name sortKey="Zanke, Brent" sort="Zanke, Brent" uniqKey="Zanke B" first="Brent" last="Zanke">Brent Zanke</name></country><country name="Australie"><noRegion><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name></noRegion><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name></country><country name="Grèce"><noRegion><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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